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KMID : 0960220080070010073
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Journal of the Korean Balance Society
2008 Volume.7 No. 1 p.73 ~ p.76
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A Case of Apogeotropic Positional Nystagmus Associated With Anti-GD1b IgG Antibody
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Jeong Seong-Hae
Oh Gun-Sei
Shin Dong-Ick
Kim Ji-Soo
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Abstract
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The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.
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KEYWORD
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Anti-GD1b IgG antibody, Apogeotropic nystagmus, Positron emission tomography
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